Regio- And Stereoselective Hydrogenation of 2-demethoxy-2’-methyldehydrogriseofulvin, A Symmetrical Substrate, To (+)-2-demethoxy-2/-methylgriseofulvin With A Cell-free System of Streptomyces Cinereocrocatus

Taiko Oda, Humie Hashimoto, Yoshihiro Sato

研究成果: Article

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Enzymatic hydrogenation of 2 ‘-demethoxy-2’-methyldehydrogriseofulvin (5) with a cell-free system of Streptomyces cinereocrocatus afforded (+)-2/-demethoxy-2'-methylgriseofulvin (6). The structure of 6 was determined on the basis of comparisons of the proton nuclear magnetic resonance spectrum, mass spectrum, and circular dichroism with those of a standard specimen which was synthesized chemically. The results demonstrated that when the 2’-position of (—)-dehydrogriseofulvin was substituted with a methyl group, its hydrogenation with the cell-free system occurred stereoselectively at the 5 ‘,6’-position.

元の言語English
ページ(範囲)525-528
ページ数4
ジャーナルChemical and Pharmaceutical Bulletin
38
発行部数2
DOI
出版物ステータスPublished - 1990 1 1

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

フィンガープリント Regio- And Stereoselective Hydrogenation of 2-demethoxy-2’-methyldehydrogriseofulvin, A Symmetrical Substrate, To (+)-2-demethoxy-2<sup>/</sup>-methylgriseofulvin With A Cell-free System of Streptomyces Cinereocrocatus' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

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