Regional cerebral glucose metabolism in patients with secondary depressive episodes after fatal pancreatic cancer diagnosis

Masatoshi Inagaki, Eisho Yoshikawa, Makoto Kobayakawa, Yutaka Matsuoka, Yuriko Sugawara, Tomohito Nakano, Nobuya Akizuki, Maiko Fujimori, Tatsuo Akechi, Taira Kinoshita, Junji Furuse, Koji Murakami, Yosuke Uchitomi

研究成果: Article査読

28 被引用数 (Scopus)

抄録

Background: Secondary depression is common in the clinical oncology setting after pancreatic cancer diagnosis, following which the patients have to face the fact that they have a cancer with an extremely poor prognosis. However, the specific pathophysiology remains unclear. The present study examined the regional cerebral glucose metabolism using F18-fluorodeoxyglucose (F18-FDG) positron emission tomography (PET) in antidepressant-naïve pancreatic cancer patients with a depressive episode after their cancer diagnosis and before their cancer treatment. Methods: Regional cerebral glucose metabolism in pancreatic cancer patients without any antidepressant medication after the cancer diagnosis was measured with F18-FDG PET. A depressive episode after the cancer diagnosis was defined as including major and minor depressive episodes, and was diagnosed using the Diagnostic and Statistical Manual, Fourth Edition (DSM-IV). The prefrontal and limbic regions were the primary regions-of-interest, and an uncorrected value of p < 0.005 was used as significant. Results: Six of 21 pancreatic cancer patients were diagnosed as having a depressive episode. Significantly higher glucose metabolism in depressed patients was found in the subgenual anterior cingulate cortex (sACC) (uncorrected p = 0.002). Limitations: There was a small number of subjects, and there were no healthy controls. Conclusions: The higher metabolism in the sACC may be associated with the pathophysiology of secondary depressive episodes in patients following pancreatic cancer diagnosis.

本文言語English
ページ(範囲)231-236
ページ数6
ジャーナルJournal of Affective Disorders
99
1-3
DOI
出版ステータスPublished - 2007 4月
外部発表はい

ASJC Scopus subject areas

  • 臨床心理学
  • 精神医学および精神衛生

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