Regioselective C-H bond cleavage/alkyne insertion under ruthenium catalysis

Yuto Hashimoto, Koji Hirano, Tetsuya Satoh, Fumitoshi Kakiuchi, Masahiro Miura

研究成果: Article査読

69 被引用数 (Scopus)

抄録

The ruthenium-catalyzed coupling reactions of benzamides with alkynes in the presence of acetic acid as a promoter smoothly proceeded regio- and stereoselectively through a directed C-H bond cleavage to produce the corresponding ortho-alkenylated products. Phenylpyrazoles and related substrates also underwent a similar coupling to give dialkenylated products selectively. Several competitive experiments were performed to obtain mechanistic insight into both the mono- and dialkenylation reactions.

本文言語English
ページ(範囲)638-646
ページ数9
ジャーナルJournal of Organic Chemistry
78
2
DOI
出版ステータスPublished - 2013 1 18

ASJC Scopus subject areas

  • 有機化学

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