Regioselective phosphorylation of: Myo -inositol with BINOL-derived phosphoramidites and its application for protozoan lysophosphatidylinositol

Toshihiko Aiba, Masaki Sato, Daichi Umegaki, Takanori Iwasaki, Nobuaki Kambe, Koichi Fukase, Yukari Fujimoto

研究成果: Article

16 引用 (Scopus)

抜粋

A regioselective phosphorylation method for myo-inositol was developed by utilizing readily preparable BINOL-derived phosphoramidites. The method also facilitated the complete separation of the diastereomeric products by simple chromatography. Based on this phosphorylation and Ni-catalyzed alkyl-alkyl cross-coupling reaction for long fatty acids, we achieved the first synthesis of a lysophosphatidylinositol, EhPIa having long fatty acid C30:1, as a partial structure of glycosylphosphatidylinositol (GPI) anchor from the cell membrane of a protozoa, Entamoeba histolytica.

元の言語English
ページ(範囲)6672-6675
ページ数4
ジャーナルOrganic and Biomolecular Chemistry
14
発行部数28
DOI
出版物ステータスPublished - 2016

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Biochemistry

フィンガープリント Regioselective phosphorylation of: Myo -inositol with BINOL-derived phosphoramidites and its application for protozoan lysophosphatidylinositol' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用