In Japan, the paper-based process of getting prescription medications leads to problems including inconvenience for patients, high government expenditure, and the lack of regulation on online counterfeit drug transactions, especially given Japan has an aging society and long-existing National Health Insurance (NHI) system. Regulated digital pharmacy (RDP) could be an innovative solution based on Electronic Health Records (EHR) and Computerized Physician Order Entry (CPOE) systems. To make the implementation of RDP more effective and secure, the authors reviewed the effectiveness of three systems that manage EHR and recommended an optimal system as a basis for RDP in Japan. The authors also suggest integrating with the recently proposed Adaptive Integrated Digital Architecture Framework (AIDAF), and integration schemes are discussed. Moreover, the challenges and future research are addressed.