Regulated virulence controls the ability of a pathogen to compete with the gut microbiota

Nobuhiko Kamada, Yun Gi Kim, Ho Pan Sham, Bruce A. Vallance, José L. Puente, Eric C. Martens, Gabriel Núñez

研究成果: Article査読

411 被引用数 (Scopus)

抄録

The virulence mechanisms that allow pathogens to colonize the intestine remain unclear. Here, we show that germ-free animals are unable to eradicate Citrobacter rodentium, a model for human infections with attaching and effacing bacteria. Early in infection, virulence genes were expressed and required for pathogen growth in conventionally raised mice but not germ-free mice. Virulence gene expression was down-regulated during the late phase of infection, which led to relocation of the pathogen to the intestinal lumen where it was outcompeted by commensals. The ability of commensals to outcompete C. rodentium was determined, at least in part, by the capacity of the pathogen and commensals to grow on structurally similar carbohydrates. Thus, pathogen colonization is controlled by bacterial virulence and through competition with metabolically related commensals.

本文言語English
ページ(範囲)1325-1329
ページ数5
ジャーナルScience
336
6086
DOI
出版ステータスPublished - 2012 6月 8
外部発表はい

ASJC Scopus subject areas

  • 一般

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