Regulation of γδ versus αβ T lymphocyte differentiation by the transcription factor SOX13

Heather J. Melichar, Kavitha Narayan, Sandy O. Der, Yoshiki Hiraoka, Noemie Gardiol, Gregoire Jeannet, Werner Held, Cynthia A. Chambers, Joonsoo Kang

研究成果: Article査読

115 被引用数 (Scopus)

抄録

αβ and γδ T cells originate from a common, multipotential precursor population in the thymus, but the molecular mechanisms regulating this lineage-fate decision are unknown. We have identified Sox13 as a γδ-specific gene in the immune system. Using Sox13 transgenic mice, we showed that this transcription factor promotes γδ T cell development while opposing αβ T cell differentiation. Conversely, mice deficient in Sox13 expression exhibited impaired development of γδ cells but not αβ T cells. One mechanism of SOX13 function is the inhibition of signaling by the developmentally important Wnt/T cell factor (TCF) pathway. Our data thus reveal a dominant pathway regulating the developmental fate of these two lineages of T lymphocytes.

本文言語English
ページ(範囲)230-233
ページ数4
ジャーナルScience
315
5809
DOI
出版ステータスPublished - 2007 1 12

ASJC Scopus subject areas

  • General

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