Regulation of cortical neuron migration by the reelin signaling pathway

Takao Honda, Kazuma Kobayashi, Katsuhiko Mikoshiba, Kazunori Nakajima

研究成果: Review article査読

60 被引用数 (Scopus)

抄録

Reeler is a mutant mouse with defects in layered structures of the central nervous system, such as the cerebral cortex, hippocampus, and cerebellum, and has been extensively examined for more than half a century. The full-length cDNA for the responsible gene for reeler, reelin, was serendipitously identified, revealing that Reelin encodes a large secreted protein. So far, two Reelin receptors, apolipoprotein E receptor 2 and very low-density lipoprotein receptor, and the cytoplasmic adaptor protein Disabled homolog 1 (Dab1) have been shown to be essential for Reelin signaling. Although a number of downstream cascades of Dab1 have also been reported using various experimental systems, the physiological functions of Reelin in vivo remain controversial. Here, we review recent advances in the understanding of the Reelin-Dab1 signaling pathway in the developing cerebral cortex.

本文言語English
ページ(範囲)1270-1279
ページ数10
ジャーナルNeurochemical Research
36
7
DOI
出版ステータスPublished - 2011 7月

ASJC Scopus subject areas

  • 生化学
  • 細胞および分子神経科学

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