Regulation of Th17 cell differentiation by intestinal commensal bacteria

研究成果: Article査読

10 被引用数 (Scopus)

抄録

Interleukin (IL)-17-producing CD4 T cells ('Th17 cells') are most abundant at the intestinal mucosa, and play a critical role in the maintenance of mucosal barrier function. Recent studies indicate that accumulation of intestinal Th17 cells depends on stimulation by intestinal commensal bacteria - particularly by segmented filamentous bacterium. In this review, we summarise recent advances in our understanding of the mechanisms of intestinal Th17 synthesis in mice, and discuss their relevance to infectious and inflammatory diseases.

本文言語English
ページ(範囲)327-334
ページ数8
ジャーナルBeneficial Microbes
1
4
DOI
出版ステータスPublished - 2010
外部発表はい

ASJC Scopus subject areas

  • 微生物学
  • 微生物学(医療)

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