TY - JOUR
T1 - Regulation of the starfish sperm acrosome reaction by cGMP, pH, cAMP and Ca2+
AU - Matsumoto, Midori
AU - Kawase, Osamu
AU - Islam, M. Sadiqul
AU - Naruse, Masahiro
AU - Watanabe, Shin Nosuke
AU - Ishikawa, Riho
AU - Hoshi, Motonori
PY - 2008
Y1 - 2008
N2 - In the starfish, Asterias amurensis, three components in the jelly coat of eggs, namely acrosome reaction-inducing substance (ARIS), Co-ARIS and asterosap, act in concert on homologous spermatozoa to induce the acrosome reaction (AR). Molecular recognition between the sperm surface molecules and the egg jelly molecules must underlie signal transduction events triggering the AR. Asterosap is a sperm-activating molecule, which stimulates rapid synthesis of intracellular cGMP, pH and Ca2+. This transient elevation of Ca2+ level is caused by a K+-dependent Na+/Ca2+ exchanger, and the increase of intracellular pH is sufficient for ARIS to induce the AR. The concerted action of ARIS and asterosap could induce elevate intracellular cAMP levels in starfish sperm and the sustained increase in [Ca2+], which is essential for the AR. The signaling pathway induced by these factors seems to be synergistically regulated to trigger the AR in starfish sperm.
AB - In the starfish, Asterias amurensis, three components in the jelly coat of eggs, namely acrosome reaction-inducing substance (ARIS), Co-ARIS and asterosap, act in concert on homologous spermatozoa to induce the acrosome reaction (AR). Molecular recognition between the sperm surface molecules and the egg jelly molecules must underlie signal transduction events triggering the AR. Asterosap is a sperm-activating molecule, which stimulates rapid synthesis of intracellular cGMP, pH and Ca2+. This transient elevation of Ca2+ level is caused by a K+-dependent Na+/Ca2+ exchanger, and the increase of intracellular pH is sufficient for ARIS to induce the AR. The concerted action of ARIS and asterosap could induce elevate intracellular cAMP levels in starfish sperm and the sustained increase in [Ca2+], which is essential for the AR. The signaling pathway induced by these factors seems to be synergistically regulated to trigger the AR in starfish sperm.
KW - Cyclic nucleotides
KW - Invertebrate fertilization
KW - Ion channel
KW - Signal transduction
KW - Spermatozoa
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U2 - 10.1387/ijdb.072511mm
DO - 10.1387/ijdb.072511mm
M3 - Article
C2 - 18649265
AN - SCOPUS:54249118709
VL - 52
SP - 523
EP - 526
JO - International Journal of Developmental Biology
JF - International Journal of Developmental Biology
SN - 0214-6282
IS - 5-6
ER -