Regulation of the type I IFN induction: A current view

Kenya Honda, Hideyuki Yanai, Akinori Takaoka, Tadatsugu Taniguchi

研究成果: Review article査読

283 被引用数 (Scopus)

抄録

The type I IFN-α/β gene family was identified about a quarter of a century ago as a prototype of many cytokine gene families, which led to the subsequent burst of studies on molecular mechanisms underlying cytokine gene expression and signaling. Although originally discovered for their activity to confer an antiviral state on cells, more evidence has recently been emerging regarding IFN-α/β actions on cell growth, differentiation and many immunoregulatory activities, which are of even greater fundamental biological significance. Indeed, much attention has recently been focused on the induction and function of the IFN-α/β system regulated by Toll-like receptors (TLRs), which are critical for linking the innate and adaptive immunities. The understanding of the regulatory mechanisms of IFN-α/β gene induction by TLRs and viruses is an emerging theme, for which much new insight has been gained over the past few years.

本文言語English
ページ(範囲)1367-1378
ページ数12
ジャーナルInternational immunology
17
11
DOI
出版ステータスPublished - 2005 11月
外部発表はい

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学

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