Regulation of TLR signaling and inflammation by SOCS family proteins

Akihiko Yoshimura, Hiroyuki Mori Masanobu Ohishi, Daisuke Aki, Toshikatsu Hanada

研究成果: Review article査読

48 被引用数 (Scopus)

抄録

Immune and inflammatory systems are controlled by multiple cytokines, including interleukins and interferons. These cytokines exert their biological functions through Janus tyrosine kinases and signal transducer and activator of transcription factors. The cytokine-inducible Src homology 2 protein (CIS) and suppressors of cytokine signaling (SOCS) are a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine responses, including those that regulate the inflammatory systems. In this short review, we focused on the molecular mechanism of the action of CIS/SOCS family proteins and their roles in Toll-like receptor signal regulation and inflammatory diseases.

本文言語English
ページ(範囲)422-427
ページ数6
ジャーナルJournal of Leukocyte Biology
75
3
DOI
出版ステータスPublished - 2004 3
外部発表はい

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Cell Biology

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