Regulatory mechanisms of immune responses to intestinal bacteria

K. Honda, K. Takeda

研究成果: Review article査読

80 被引用数 (Scopus)

抄録

The intestinal mucosa allows the residence of trillions of bacteria with which it interacts dynamically. To establish and maintain a mutually beneficial relationship, the mucosal immune system must enforce tolerance toward the vast non-pathogenic microbiota while simultaneously remaining reactive to potentially pathogenic microbes; the disruption of this delicate balance results in inflammatory bowel diseases. In this review, we describe advances in our understanding of regulatory mechanisms of the innate immune system and how these shape adaptive immune systems during steady-state and inflammatory processes in the intestinal mucosa.

本文言語English
ページ(範囲)187-196
ページ数10
ジャーナルMucosal Immunology
2
3
DOI
出版ステータスPublished - 2009
外部発表はい

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学

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