Regulatory T cells and inflammatory bowel diseases

Takanori Kanai, Mamoru Watanabe

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Crohn’s disease and ulcerative colitis are two major forms of human inflammatory bowel diseases (IBD). Their etiology is unknown, but increasing evidence indicate that immune mechanisms play an important role. It is well known that immune responses in the intestine remain in a state of controlled inflammation, suggesting that not only active suppression by regulatory T (TR) cells plays an important role in the normal intestinal homeostasis, but also its dysregula-tion leads to the development of IBD. This article reviews the unique aspects of TR cells and discuss how these control the intestinal homeostasis.

本文言語English
ページ(範囲)302-308
ページ数7
ジャーナルJapanese Journal of Clinical Immunology
27
5
DOI
出版ステータスPublished - 2004
外部発表はい

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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