Relation of gamma-glutamyltransferase and alcohol drinking with incident diabetes: The HIPOP-OHP study

Atsushi Hozawa, Tomonori Okamura, Taichiro Tanaka, Katsuyuki Miura, Yuriko Kikuchi, Takashi Kadowaki, Katsushi Yoshita, Toru Takebayashi, Junko Tamaki, Junko Minai, Takayo Tada, Nagako Chiba, Akira Okayama, Hirotsugu Ueshima

研究成果: Article

5 引用 (Scopus)

抄録

Aim: Gamma-glutamyltransferase (GGT) is known to correlate well with alcohol consumption; however, the relation between GGT and diabetes and that between alcohol consumption and diabetes mellitus (DM) is inconsistent. Thus, several questions, such as whether light to moderate drinkers can be considered as low risk for diabetes incidence irrespective of their GGT level, is unresolved. In this study, we investigated the relation of GGT or alcohol drinking with DM incidence considering the body mass index (BMI) in healthy Japanese workers. Methods: We followed 3095 men who did not have DM at baseline for 4 years. Incident diabetes was defined as a fasting (non-fasting) plasma glucose level of ≥7.0 (11.1) mmol/L, or treatment of diabetes. Multiple adjusted hazard ratios (HR) were calculated using Cox proportional models. Results: Participants with higher GGT (GGT ≥27 IU/L) showed an increased risk of diabetes incidence even when their BMI level was low. Although a U-shaped relation between alcohol drinking and incident diabetes was observed, the risk to light to moderate drinkers (alcohol <23 g/day) was not low if they were either overweight (BMI ≥25 kg/m2) or had higher GGT (HR= 2.60, p= 0.08) or both overweight and higher GGT (HR= 3.16, p= 0.07) compared with never drinkers without higher GGT and overweight. Conclusions: Higher GGT was associated with a higher incidence of DM irrespective of drinking status or obesity. Although a U-shaped relation between alcohol drinking and incident diabetes was observed, the risk to light to moderate drinkers was not low if they were either overweight or had higher GGT.

元の言語English
ページ(範囲)195-202
ページ数8
ジャーナルJournal of Atherosclerosis and Thrombosis
17
発行部数2
出版物ステータスPublished - 2010

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gamma-Glutamyltransferase
Medical problems
Alcohol Drinking
Alcohols
Diabetes Mellitus
Hazards
Body Mass Index
Incidence
Light
Proportional Hazards Models
Drinking
Fasting
Obesity
Plasmas
Glucose

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Internal Medicine
  • Biochemistry, medical

これを引用

Hozawa, A., Okamura, T., Tanaka, T., Miura, K., Kikuchi, Y., Kadowaki, T., ... Ueshima, H. (2010). Relation of gamma-glutamyltransferase and alcohol drinking with incident diabetes: The HIPOP-OHP study. Journal of Atherosclerosis and Thrombosis, 17(2), 195-202.

Relation of gamma-glutamyltransferase and alcohol drinking with incident diabetes : The HIPOP-OHP study. / Hozawa, Atsushi; Okamura, Tomonori; Tanaka, Taichiro; Miura, Katsuyuki; Kikuchi, Yuriko; Kadowaki, Takashi; Yoshita, Katsushi; Takebayashi, Toru; Tamaki, Junko; Minai, Junko; Tada, Takayo; Chiba, Nagako; Okayama, Akira; Ueshima, Hirotsugu.

:: Journal of Atherosclerosis and Thrombosis, 巻 17, 番号 2, 2010, p. 195-202.

研究成果: Article

Hozawa, A, Okamura, T, Tanaka, T, Miura, K, Kikuchi, Y, Kadowaki, T, Yoshita, K, Takebayashi, T, Tamaki, J, Minai, J, Tada, T, Chiba, N, Okayama, A & Ueshima, H 2010, 'Relation of gamma-glutamyltransferase and alcohol drinking with incident diabetes: The HIPOP-OHP study', Journal of Atherosclerosis and Thrombosis, 巻. 17, 番号 2, pp. 195-202.
Hozawa, Atsushi ; Okamura, Tomonori ; Tanaka, Taichiro ; Miura, Katsuyuki ; Kikuchi, Yuriko ; Kadowaki, Takashi ; Yoshita, Katsushi ; Takebayashi, Toru ; Tamaki, Junko ; Minai, Junko ; Tada, Takayo ; Chiba, Nagako ; Okayama, Akira ; Ueshima, Hirotsugu. / Relation of gamma-glutamyltransferase and alcohol drinking with incident diabetes : The HIPOP-OHP study. :: Journal of Atherosclerosis and Thrombosis. 2010 ; 巻 17, 番号 2. pp. 195-202.
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abstract = "Aim: Gamma-glutamyltransferase (GGT) is known to correlate well with alcohol consumption; however, the relation between GGT and diabetes and that between alcohol consumption and diabetes mellitus (DM) is inconsistent. Thus, several questions, such as whether light to moderate drinkers can be considered as low risk for diabetes incidence irrespective of their GGT level, is unresolved. In this study, we investigated the relation of GGT or alcohol drinking with DM incidence considering the body mass index (BMI) in healthy Japanese workers. Methods: We followed 3095 men who did not have DM at baseline for 4 years. Incident diabetes was defined as a fasting (non-fasting) plasma glucose level of ≥7.0 (11.1) mmol/L, or treatment of diabetes. Multiple adjusted hazard ratios (HR) were calculated using Cox proportional models. Results: Participants with higher GGT (GGT ≥27 IU/L) showed an increased risk of diabetes incidence even when their BMI level was low. Although a U-shaped relation between alcohol drinking and incident diabetes was observed, the risk to light to moderate drinkers (alcohol <23 g/day) was not low if they were either overweight (BMI ≥25 kg/m2) or had higher GGT (HR= 2.60, p= 0.08) or both overweight and higher GGT (HR= 3.16, p= 0.07) compared with never drinkers without higher GGT and overweight. Conclusions: Higher GGT was associated with a higher incidence of DM irrespective of drinking status or obesity. Although a U-shaped relation between alcohol drinking and incident diabetes was observed, the risk to light to moderate drinkers was not low if they were either overweight or had higher GGT.",
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author = "Atsushi Hozawa and Tomonori Okamura and Taichiro Tanaka and Katsuyuki Miura and Yuriko Kikuchi and Takashi Kadowaki and Katsushi Yoshita and Toru Takebayashi and Junko Tamaki and Junko Minai and Takayo Tada and Nagako Chiba and Akira Okayama and Hirotsugu Ueshima",
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TY - JOUR

T1 - Relation of gamma-glutamyltransferase and alcohol drinking with incident diabetes

T2 - The HIPOP-OHP study

AU - Hozawa, Atsushi

AU - Okamura, Tomonori

AU - Tanaka, Taichiro

AU - Miura, Katsuyuki

AU - Kikuchi, Yuriko

AU - Kadowaki, Takashi

AU - Yoshita, Katsushi

AU - Takebayashi, Toru

AU - Tamaki, Junko

AU - Minai, Junko

AU - Tada, Takayo

AU - Chiba, Nagako

AU - Okayama, Akira

AU - Ueshima, Hirotsugu

PY - 2010

Y1 - 2010

N2 - Aim: Gamma-glutamyltransferase (GGT) is known to correlate well with alcohol consumption; however, the relation between GGT and diabetes and that between alcohol consumption and diabetes mellitus (DM) is inconsistent. Thus, several questions, such as whether light to moderate drinkers can be considered as low risk for diabetes incidence irrespective of their GGT level, is unresolved. In this study, we investigated the relation of GGT or alcohol drinking with DM incidence considering the body mass index (BMI) in healthy Japanese workers. Methods: We followed 3095 men who did not have DM at baseline for 4 years. Incident diabetes was defined as a fasting (non-fasting) plasma glucose level of ≥7.0 (11.1) mmol/L, or treatment of diabetes. Multiple adjusted hazard ratios (HR) were calculated using Cox proportional models. Results: Participants with higher GGT (GGT ≥27 IU/L) showed an increased risk of diabetes incidence even when their BMI level was low. Although a U-shaped relation between alcohol drinking and incident diabetes was observed, the risk to light to moderate drinkers (alcohol <23 g/day) was not low if they were either overweight (BMI ≥25 kg/m2) or had higher GGT (HR= 2.60, p= 0.08) or both overweight and higher GGT (HR= 3.16, p= 0.07) compared with never drinkers without higher GGT and overweight. Conclusions: Higher GGT was associated with a higher incidence of DM irrespective of drinking status or obesity. Although a U-shaped relation between alcohol drinking and incident diabetes was observed, the risk to light to moderate drinkers was not low if they were either overweight or had higher GGT.

AB - Aim: Gamma-glutamyltransferase (GGT) is known to correlate well with alcohol consumption; however, the relation between GGT and diabetes and that between alcohol consumption and diabetes mellitus (DM) is inconsistent. Thus, several questions, such as whether light to moderate drinkers can be considered as low risk for diabetes incidence irrespective of their GGT level, is unresolved. In this study, we investigated the relation of GGT or alcohol drinking with DM incidence considering the body mass index (BMI) in healthy Japanese workers. Methods: We followed 3095 men who did not have DM at baseline for 4 years. Incident diabetes was defined as a fasting (non-fasting) plasma glucose level of ≥7.0 (11.1) mmol/L, or treatment of diabetes. Multiple adjusted hazard ratios (HR) were calculated using Cox proportional models. Results: Participants with higher GGT (GGT ≥27 IU/L) showed an increased risk of diabetes incidence even when their BMI level was low. Although a U-shaped relation between alcohol drinking and incident diabetes was observed, the risk to light to moderate drinkers (alcohol <23 g/day) was not low if they were either overweight (BMI ≥25 kg/m2) or had higher GGT (HR= 2.60, p= 0.08) or both overweight and higher GGT (HR= 3.16, p= 0.07) compared with never drinkers without higher GGT and overweight. Conclusions: Higher GGT was associated with a higher incidence of DM irrespective of drinking status or obesity. Although a U-shaped relation between alcohol drinking and incident diabetes was observed, the risk to light to moderate drinkers was not low if they were either overweight or had higher GGT.

KW - Alcohol consumption

KW - Diabetes mellitus

KW - Gamma-glutamyltransferase

KW - Prospective studies

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C2 - 20150721

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VL - 17

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EP - 202

JO - Journal of Atherosclerosis and Thrombosis

JF - Journal of Atherosclerosis and Thrombosis

SN - 1340-3478

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