Relationship between neutrophil influx and oxidative stress in alveolar space in lipopolysaccharide-induced lung injury

T. Yoshida, K. Nagai, T. Inomata, Y. Ito, T. Betsuyaku, M. Nishimura

研究成果: Article査読

17 被引用数 (Scopus)

抄録

We intratracheally administered lipopolysaccharide (LPS) to ICR mice and then collected BAL fluid and lung tissue to determine whether levels of neutrophils and/or myeloperoxidase (MPO) in bronchoalveolar lavage (BAL) fluid reflect lung tissue damage. Robust neutrophil accumulation into the alveolar space and lung tissue were almost completely abolished at seven days along with oxidative stress markers in the lung. However, lung injury scores and lung wet/dry ratios, as well as MPO and oxidative stress markers in BAL fluid were significantly increased at five and seven days after LPS administration. At later time points, BAL neutrophils generated more MPO activity and ROS than those harvested sooner after LPS administration. Although elevated neutrophil levels in BAL fluid reflected oxidative stress in the lungs, MPO might serve as a useful marker to evaluate damage sustained by epithelial cells over the long term.

本文言語English
ページ(範囲)75-83
ページ数9
ジャーナルRespiratory Physiology and Neurobiology
191
1
DOI
出版ステータスPublished - 2014 1 15
外部発表はい

ASJC Scopus subject areas

  • 神経科学(全般)
  • 生理学
  • 呼吸器内科

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