Relationship between thin physique at 6 years and metabolic disease risks in middle-aged Japanese women: The Suita study

Shinji Katsuragi, Tomonori Okamura, Yoshihiro Kokubo, Makoto Watanabe, Aya Higashiyama, Tomoaki Ikeda, Yoshihiro Miyamoto

研究成果: Article査読

抄録

Aim: We previously reported that female babies born small developed cardiovascular risks in middle age. The present study was conducted using the same cohort to examine the relationship between physique at 6 years and the metabolic disease risk in middle age. Methods: Data collected from 721 women aged 41–69 years who underwent a medical examination at a single institution between 2007 and 2008 were retrospectively examined. We collected data from medical examinations and a questionnaire on physique (thin, normal, and fat) at 6 years. The relationship between birthweight and physique at 6 years was investigated. Results: Among females who were born small (< 2500 g), 80%, 16%, and 4% became thin, normal, or fat, respectively, by 6 years. Physique at 6 years had a negative relationship with future triglyceride, fasting glucose, HbA1C, insulin, and homeostasis model assessment of insulin resistance (HOMA-IR) levels and a positive relationship with high-density lipoprotein cholesterol levels. Conclusion: Although our findings may be specific to the study population, physique at 6 years had a negative relationship with the metabolic disease risk in middle-aged Japanese women. Insulin and MOMA-IR levels negatively correlated with physique at 6 years, and development from low birthweight infants to childhood obesity was rare in this cohort.

本文言語English
ページ(範囲)517-526
ページ数10
ジャーナルJournal of Obstetrics and Gynaecology Research
46
3
DOI
出版ステータスPublished - 2020 3月 1

ASJC Scopus subject areas

  • 産婦人科学

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