Relative antidipsogenic potencies of six homologous natriuretic peptides in eels

Hiroshi Miyanishi, Shigenori Nobata, Yoshio Takei

研究成果: Article

6 引用 (Scopus)

抄録

Atrial natriuretic peptide (ANP) exhibits a potent antidipsogenic effect in seawater (SW) eels to limit excess Na + uptake, thereby effectively promoting SW adaptation. Recently, cardiac ANP, BNP and VNP and brain CNP1, 3 and 4, have been identified in eels. We examined the antidipsogenic effect of all homologous NPs using conscious, cannulated eels in both FW and SW together with parameters that affect drinking. A dose-response study (0.011 nmol/kg) in SW eels showed the relative potency of the antidipsogenic effect was in the order ANP ≥ VNP > BNP = CNP3 > CNP1 ≥ CNP4, while the order was ANP = VNP = BNP > CNP3 = CNP1 = CNP4 for the vasodepressor effect. The minimum effective dose of ANP for the antidipsogenic effect is much lower than that in mammals. ANP, BNP and VNP at 0.3 nmol/kg decreased drinking, plasma Na + concentration and aortic pressure and increased hematocrit in SW eels. The cardiac NPs induced similar changes in drinking, aortic pressure and hematocrit in FW eels, but aside from BNP no change in plasma Na + concentration. CNPs had no effect on drinking, plasma Na + concentration and hematocrit but induced mild hypotension in both FW and SW eels, except for CNP3 that inhibited drinking in SW eels. These results show that ANP, BNP and VNP are potent antidipsogenic hormones in eels in spite of other regulatory factors working to induce drinking, and that CNPs are without effects on drinking except for the ancestor of the cardiac NPs, CNP3.

元の言語English
ページ(範囲)719-726
ページ数8
ジャーナルZoological Science
28
発行部数10
DOI
出版物ステータスPublished - 2011 10
外部発表Yes

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natriuretic peptides
eel
atrial natriuretic peptide
drinking
seawater
hematocrit
hypotension
dose response
ancestry
hormones
mammals
uptake mechanisms
brain

ASJC Scopus subject areas

  • Animal Science and Zoology

これを引用

Relative antidipsogenic potencies of six homologous natriuretic peptides in eels. / Miyanishi, Hiroshi; Nobata, Shigenori; Takei, Yoshio.

:: Zoological Science, 巻 28, 番号 10, 10.2011, p. 719-726.

研究成果: Article

Miyanishi, Hiroshi ; Nobata, Shigenori ; Takei, Yoshio. / Relative antidipsogenic potencies of six homologous natriuretic peptides in eels. :: Zoological Science. 2011 ; 巻 28, 番号 10. pp. 719-726.
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