Relaxin and myometrial activity

Takuro Osa, Hiroyoshi Inoue, Koji Okabe

研究成果: Article査読

抄録

The research on intracellular signal transduction and the smooth muscle contraction have made much progress since 1970. Effects of relaxin, a peptide hormone mainly produced and released from ovary, are reviewed in the above point of view. Cyclic AMP content in myometrial cells is increased by relaxin. One site of relaxin action can be the suppression of myosin light chain kinase activity. Another effect of relaxin is the suppression of action potential, whereby the Ca-influx is reduced. However, relaxin up to 300 mU does not hyperpolarize the myometrial membrane of estrogen-primed rat, which differs from the adrenergic β-action. Unrealed signal transduction seems involved in the relaxin action.

本文言語English
ページ(範囲)67-74
ページ数8
ジャーナルJournal of Smooth Muscle Research
27
1
DOI
出版ステータスPublished - 1991

ASJC Scopus subject areas

  • 生理学

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