Renal cell carcinoma in children: Experience at a single institution in Japan

Hiroshi Asanuma, Hideo Nakai, Masashi Takeda, Seiichiro Shishido, Eiji Tajima, Takeshi Kawamura, Hiroko Hara, Yukihiko Morikawa, Takeshi Kawamura

研究成果: Article

35 引用 (Scopus)

抄録

Purpose: We analyzed the presentation, treatment and survival of 4 children with renal cell carcinoma. Materials and Methods: We retrospectively reviewed the pathological and hospital records of 4 Japanese children diagnosed with renal cell carcinoma at our hospital from 1970 to 1998. Results: In the 1 boy and 3 girls with an average age of 8 years 7 months at diagnosis the most common presenting complaints were gross hematuria in 75% and a palpable abdominal mass in 50%. Computerized tomography revealed characteristic calcification within the tumor in 3 of the 4 patients (75%). In the remaining case the lesion had high density areas with microcalcification, as confirmed by histopathological study. In 2 patients with regional lymph node metastasis calcification was also observed in the metastatic lesions. Disease was stages I to III in 1, 1 and 2 patients, respectively. All patients underwent transabdominal nephrectomy with regional lymphadenectomy. One patient with stage I disease had multiple metastases 15 months later and died of disease 55 months postoperatively. However, the remaining 3 patients received adjuvant interferon therapy and they are without evidence of recurrence a mean of 51.3 months postoperatively. Conclusions: Calcification within the tumor and/or metastatic lesions or high density areas in the tumor on screening computerized tomography are characteristic findings suggestive of pediatric renal cell carcinoma. Adjuvant therapy with interferon may provide some benefit in select pediatric patients. Further studies of a larger number of pediatric renal cell carcinoma cases may be necessary to establish the optimal diagnostic and therapeutic regimen.

元の言語English
ページ(範囲)1402-1405
ページ数4
ジャーナルJournal of Urology
162
発行部数4
DOI
出版物ステータスPublished - 1999 10
外部発表Yes

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Renal Cell Carcinoma
Japan
Pediatrics
Interferons
Tomography
Neoplasm Metastasis
Calcinosis
Neoplasms
Hospital Records
Hematuria
Therapeutics
Lymph Node Excision
Nephrectomy
Lymph Nodes
Recurrence
Survival

ASJC Scopus subject areas

  • Urology

これを引用

Asanuma, H., Nakai, H., Takeda, M., Shishido, S., Tajima, E., Kawamura, T., ... Kawamura, T. (1999). Renal cell carcinoma in children: Experience at a single institution in Japan. Journal of Urology, 162(4), 1402-1405. https://doi.org/10.1016/S0022-5347(05)68321-8

Renal cell carcinoma in children : Experience at a single institution in Japan. / Asanuma, Hiroshi; Nakai, Hideo; Takeda, Masashi; Shishido, Seiichiro; Tajima, Eiji; Kawamura, Takeshi; Hara, Hiroko; Morikawa, Yukihiko; Kawamura, Takeshi.

:: Journal of Urology, 巻 162, 番号 4, 10.1999, p. 1402-1405.

研究成果: Article

Asanuma, H, Nakai, H, Takeda, M, Shishido, S, Tajima, E, Kawamura, T, Hara, H, Morikawa, Y & Kawamura, T 1999, 'Renal cell carcinoma in children: Experience at a single institution in Japan', Journal of Urology, 巻. 162, 番号 4, pp. 1402-1405. https://doi.org/10.1016/S0022-5347(05)68321-8
Asanuma, Hiroshi ; Nakai, Hideo ; Takeda, Masashi ; Shishido, Seiichiro ; Tajima, Eiji ; Kawamura, Takeshi ; Hara, Hiroko ; Morikawa, Yukihiko ; Kawamura, Takeshi. / Renal cell carcinoma in children : Experience at a single institution in Japan. :: Journal of Urology. 1999 ; 巻 162, 番号 4. pp. 1402-1405.
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T2 - Experience at a single institution in Japan

AU - Asanuma, Hiroshi

AU - Nakai, Hideo

AU - Takeda, Masashi

AU - Shishido, Seiichiro

AU - Tajima, Eiji

AU - Kawamura, Takeshi

AU - Hara, Hiroko

AU - Morikawa, Yukihiko

AU - Kawamura, Takeshi

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N2 - Purpose: We analyzed the presentation, treatment and survival of 4 children with renal cell carcinoma. Materials and Methods: We retrospectively reviewed the pathological and hospital records of 4 Japanese children diagnosed with renal cell carcinoma at our hospital from 1970 to 1998. Results: In the 1 boy and 3 girls with an average age of 8 years 7 months at diagnosis the most common presenting complaints were gross hematuria in 75% and a palpable abdominal mass in 50%. Computerized tomography revealed characteristic calcification within the tumor in 3 of the 4 patients (75%). In the remaining case the lesion had high density areas with microcalcification, as confirmed by histopathological study. In 2 patients with regional lymph node metastasis calcification was also observed in the metastatic lesions. Disease was stages I to III in 1, 1 and 2 patients, respectively. All patients underwent transabdominal nephrectomy with regional lymphadenectomy. One patient with stage I disease had multiple metastases 15 months later and died of disease 55 months postoperatively. However, the remaining 3 patients received adjuvant interferon therapy and they are without evidence of recurrence a mean of 51.3 months postoperatively. Conclusions: Calcification within the tumor and/or metastatic lesions or high density areas in the tumor on screening computerized tomography are characteristic findings suggestive of pediatric renal cell carcinoma. Adjuvant therapy with interferon may provide some benefit in select pediatric patients. Further studies of a larger number of pediatric renal cell carcinoma cases may be necessary to establish the optimal diagnostic and therapeutic regimen.

AB - Purpose: We analyzed the presentation, treatment and survival of 4 children with renal cell carcinoma. Materials and Methods: We retrospectively reviewed the pathological and hospital records of 4 Japanese children diagnosed with renal cell carcinoma at our hospital from 1970 to 1998. Results: In the 1 boy and 3 girls with an average age of 8 years 7 months at diagnosis the most common presenting complaints were gross hematuria in 75% and a palpable abdominal mass in 50%. Computerized tomography revealed characteristic calcification within the tumor in 3 of the 4 patients (75%). In the remaining case the lesion had high density areas with microcalcification, as confirmed by histopathological study. In 2 patients with regional lymph node metastasis calcification was also observed in the metastatic lesions. Disease was stages I to III in 1, 1 and 2 patients, respectively. All patients underwent transabdominal nephrectomy with regional lymphadenectomy. One patient with stage I disease had multiple metastases 15 months later and died of disease 55 months postoperatively. However, the remaining 3 patients received adjuvant interferon therapy and they are without evidence of recurrence a mean of 51.3 months postoperatively. Conclusions: Calcification within the tumor and/or metastatic lesions or high density areas in the tumor on screening computerized tomography are characteristic findings suggestive of pediatric renal cell carcinoma. Adjuvant therapy with interferon may provide some benefit in select pediatric patients. Further studies of a larger number of pediatric renal cell carcinoma cases may be necessary to establish the optimal diagnostic and therapeutic regimen.

KW - Carcinoma

KW - Immunotherapy

KW - Interferons

KW - Kidney

KW - Renal cell

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