Renal function and outcome of out-of-hospital cardiac arrest ― Multicenter prospective study (SOS-KANTO 2012 study) ―

SOS-KANTO 2012 study group

研究成果: Article

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Background: Renal dysfunction is associated with increased cardiovascular-related mortality, but its impact on outcome of out-of-hospital cardiac arrest (OHCA) remains unclear. We assessed whether post-OHCA outcome correlated with renal function early after OHCA. Methods and Results: Of the 16,452 registered patients in the SOS-KANTO 2012 Study, 5,112 cardiogenic OHCA adults with creatinine measurement (mean age, 72 years; male, 64%) were examined. First-obtained creatinine was used to assess eGFR. Associations between eGFR groups, ≥60 (n=997), 45–59 (n=1,311), 30–44 (n=1,441), and <30 mL/min/1.73 m2 (n=1,363), and 3-month survival and neurological outcomes were examined. Favorable neurological outcome was defined as cerebral performance categories 1 or 2. Survival rate (15.1%, 9.7%, 3.9%, and 2.9%; P<0.001) and proportion of favorable neurological outcome (12.3%, 7.4%, 2.6%, and 2.2%; P<0.001) were determined for eGFR groups ≥60, 45–59, 30–44, and <30 mL/min/1.73 m2, respectively. The survival rate decreased with eGFR (<60 mL/min/1.73 m2), and survival adjusted OR were 0.74 (95% CI: 0.54–1.03), 0.42 (95% CI: 0.28–0.62), and 0.43 (95% CI: 0.28–0.68) for eGFR 45–59, 30–44, and <30 mL/min/1.73 m2, respectively. The adjusted OR for favorable neurological outcome also decreased with eGFR: 0.74 (95% CI: 0.52–1.06), 0.40 (95% CI: 0.25–0.64), and 0.48 (95% CI: 0.29–0.81), respectively. Conclusions: An independent and graded association was observed between decreased eGFR and 3-month survival and proportion of favorable neurological outcome in cardiogenic OHCA patients.

元の言語English
ページ(範囲)139-146
ページ数8
ジャーナルCirculation Journal
83
発行部数1
DOI
出版物ステータスPublished - 2019 1 1

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Out-of-Hospital Cardiac Arrest
Multicenter Studies
Prospective Studies
Kidney
Survival
Creatinine
Survival Rate
Mortality

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

これを引用

Renal function and outcome of out-of-hospital cardiac arrest ― Multicenter prospective study (SOS-KANTO 2012 study) ―. / SOS-KANTO 2012 study group.

:: Circulation Journal, 巻 83, 番号 1, 01.01.2019, p. 139-146.

研究成果: Article

@article{74b6d049e71c409b9ea1ed33237feb5e,
title = "Renal function and outcome of out-of-hospital cardiac arrest ― Multicenter prospective study (SOS-KANTO 2012 study) ―",
abstract = "Background: Renal dysfunction is associated with increased cardiovascular-related mortality, but its impact on outcome of out-of-hospital cardiac arrest (OHCA) remains unclear. We assessed whether post-OHCA outcome correlated with renal function early after OHCA. Methods and Results: Of the 16,452 registered patients in the SOS-KANTO 2012 Study, 5,112 cardiogenic OHCA adults with creatinine measurement (mean age, 72 years; male, 64{\%}) were examined. First-obtained creatinine was used to assess eGFR. Associations between eGFR groups, ≥60 (n=997), 45–59 (n=1,311), 30–44 (n=1,441), and <30 mL/min/1.73 m2 (n=1,363), and 3-month survival and neurological outcomes were examined. Favorable neurological outcome was defined as cerebral performance categories 1 or 2. Survival rate (15.1{\%}, 9.7{\%}, 3.9{\%}, and 2.9{\%}; P<0.001) and proportion of favorable neurological outcome (12.3{\%}, 7.4{\%}, 2.6{\%}, and 2.2{\%}; P<0.001) were determined for eGFR groups ≥60, 45–59, 30–44, and <30 mL/min/1.73 m2, respectively. The survival rate decreased with eGFR (<60 mL/min/1.73 m2), and survival adjusted OR were 0.74 (95{\%} CI: 0.54–1.03), 0.42 (95{\%} CI: 0.28–0.62), and 0.43 (95{\%} CI: 0.28–0.68) for eGFR 45–59, 30–44, and <30 mL/min/1.73 m2, respectively. The adjusted OR for favorable neurological outcome also decreased with eGFR: 0.74 (95{\%} CI: 0.52–1.06), 0.40 (95{\%} CI: 0.25–0.64), and 0.48 (95{\%} CI: 0.29–0.81), respectively. Conclusions: An independent and graded association was observed between decreased eGFR and 3-month survival and proportion of favorable neurological outcome in cardiogenic OHCA patients.",
keywords = "Cardiovascular disease, Neurological outcome, Out-of-hospital cardiac arrest, Renal function, Survival",
author = "{SOS-KANTO 2012 study group} and Tomoyoshi Tamura and Masaru Suzuki and Kei Hayashida and Junichi Sasaki and Naohiro Yonemoto and Atsushi Sakurai and Yoshio Tahara and Ken Nagao and Arino Yaguchi and Naoto Morimura",
year = "2019",
month = "1",
day = "1",
doi = "10.1253/circj.CJ-18-0631",
language = "English",
volume = "83",
pages = "139--146",
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publisher = "Japanese Circulation Society",
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T1 - Renal function and outcome of out-of-hospital cardiac arrest ― Multicenter prospective study (SOS-KANTO 2012 study) ―

AU - SOS-KANTO 2012 study group

AU - Tamura, Tomoyoshi

AU - Suzuki, Masaru

AU - Hayashida, Kei

AU - Sasaki, Junichi

AU - Yonemoto, Naohiro

AU - Sakurai, Atsushi

AU - Tahara, Yoshio

AU - Nagao, Ken

AU - Yaguchi, Arino

AU - Morimura, Naoto

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: Renal dysfunction is associated with increased cardiovascular-related mortality, but its impact on outcome of out-of-hospital cardiac arrest (OHCA) remains unclear. We assessed whether post-OHCA outcome correlated with renal function early after OHCA. Methods and Results: Of the 16,452 registered patients in the SOS-KANTO 2012 Study, 5,112 cardiogenic OHCA adults with creatinine measurement (mean age, 72 years; male, 64%) were examined. First-obtained creatinine was used to assess eGFR. Associations between eGFR groups, ≥60 (n=997), 45–59 (n=1,311), 30–44 (n=1,441), and <30 mL/min/1.73 m2 (n=1,363), and 3-month survival and neurological outcomes were examined. Favorable neurological outcome was defined as cerebral performance categories 1 or 2. Survival rate (15.1%, 9.7%, 3.9%, and 2.9%; P<0.001) and proportion of favorable neurological outcome (12.3%, 7.4%, 2.6%, and 2.2%; P<0.001) were determined for eGFR groups ≥60, 45–59, 30–44, and <30 mL/min/1.73 m2, respectively. The survival rate decreased with eGFR (<60 mL/min/1.73 m2), and survival adjusted OR were 0.74 (95% CI: 0.54–1.03), 0.42 (95% CI: 0.28–0.62), and 0.43 (95% CI: 0.28–0.68) for eGFR 45–59, 30–44, and <30 mL/min/1.73 m2, respectively. The adjusted OR for favorable neurological outcome also decreased with eGFR: 0.74 (95% CI: 0.52–1.06), 0.40 (95% CI: 0.25–0.64), and 0.48 (95% CI: 0.29–0.81), respectively. Conclusions: An independent and graded association was observed between decreased eGFR and 3-month survival and proportion of favorable neurological outcome in cardiogenic OHCA patients.

AB - Background: Renal dysfunction is associated with increased cardiovascular-related mortality, but its impact on outcome of out-of-hospital cardiac arrest (OHCA) remains unclear. We assessed whether post-OHCA outcome correlated with renal function early after OHCA. Methods and Results: Of the 16,452 registered patients in the SOS-KANTO 2012 Study, 5,112 cardiogenic OHCA adults with creatinine measurement (mean age, 72 years; male, 64%) were examined. First-obtained creatinine was used to assess eGFR. Associations between eGFR groups, ≥60 (n=997), 45–59 (n=1,311), 30–44 (n=1,441), and <30 mL/min/1.73 m2 (n=1,363), and 3-month survival and neurological outcomes were examined. Favorable neurological outcome was defined as cerebral performance categories 1 or 2. Survival rate (15.1%, 9.7%, 3.9%, and 2.9%; P<0.001) and proportion of favorable neurological outcome (12.3%, 7.4%, 2.6%, and 2.2%; P<0.001) were determined for eGFR groups ≥60, 45–59, 30–44, and <30 mL/min/1.73 m2, respectively. The survival rate decreased with eGFR (<60 mL/min/1.73 m2), and survival adjusted OR were 0.74 (95% CI: 0.54–1.03), 0.42 (95% CI: 0.28–0.62), and 0.43 (95% CI: 0.28–0.68) for eGFR 45–59, 30–44, and <30 mL/min/1.73 m2, respectively. The adjusted OR for favorable neurological outcome also decreased with eGFR: 0.74 (95% CI: 0.52–1.06), 0.40 (95% CI: 0.25–0.64), and 0.48 (95% CI: 0.29–0.81), respectively. Conclusions: An independent and graded association was observed between decreased eGFR and 3-month survival and proportion of favorable neurological outcome in cardiogenic OHCA patients.

KW - Cardiovascular disease

KW - Neurological outcome

KW - Out-of-hospital cardiac arrest

KW - Renal function

KW - Survival

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U2 - 10.1253/circj.CJ-18-0631

DO - 10.1253/circj.CJ-18-0631

M3 - Article

C2 - 30333435

AN - SCOPUS:85059099753

VL - 83

SP - 139

EP - 146

JO - Circulation Journal

JF - Circulation Journal

SN - 1346-9843

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