Requirement of CD9 on the egg plasma membrane for fertilization

K. Miyado, G. Yamada, S. Yamada, H. Hasuwa, Y. Nakamura, F. Ryu, K. Suzuki, K. Kosai, K. Inoue, A. Ogura, M. Okabe, E. Mekada

研究成果: Article

498 引用 (Scopus)

抜粋

CD9 is an integral membrane protein associated with integrins and other membrane proteins. Mice lacking CD9 were produced by homologous recombination. Both male and female CD9(-/-) mice were born healthy and grew normally. However, the litter size from CD9(-/-) females was less than 2% of that of the wild type. In vitro fertilization experiments indicated that the cause of this infertility was due to the failure of sperm-egg fusion. When sperm were injected into oocytes with assisted microfertilization techniques, however, the fertilized eggs developed to term. These results indicate that CD9 has a crucial role in sperm-egg fusion.

元の言語English
ページ(範囲)321-324
ページ数4
ジャーナルScience
287
発行部数5451
DOI
出版物ステータスPublished - 2000
外部発表Yes

ASJC Scopus subject areas

  • General

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    Miyado, K., Yamada, G., Yamada, S., Hasuwa, H., Nakamura, Y., Ryu, F., Suzuki, K., Kosai, K., Inoue, K., Ogura, A., Okabe, M., & Mekada, E. (2000). Requirement of CD9 on the egg plasma membrane for fertilization. Science, 287(5451), 321-324. https://doi.org/10.1126/science.287.5451.321