Reshaping circadian metabolism in the suprachiasmatic nucleus and prefrontal cortex by nutritional challenge

Paola Tognini, Muntaha Samad, Kenichiro Kinouchi, Yu Liu, Jean Christophe Helbling, Marie Pierre Moisan, Kristin L. Eckel-Mahan, Pierre Baldi, Paolo Sassone-Corsi

研究成果: Article査読

14 被引用数 (Scopus)

抄録

Food is a powerful entrainment cue for circadian clocks in peripheral tissues, and changes in the composition of nutrients have been demonstrated to metabolically reprogram peripheral clocks. However, how food challenges may influence circadian metabolism of the master clock in the suprachiasmatic nucleus (SCN) or in other brain areas is poorly understood. Using high-throughput metabolomics, we studied the circadian metabolome profiles of the SCN and medial prefrontal cortex (mPFC) in lean mice compared with mice challenged with a high-fat diet (HFD). Both the mPFC and the SCN displayed a robust cyclic metabolism, with a strikingly high sensitivity to HFD perturbation in an area-specific manner. The phase and amplitude of oscillations were drastically different between the SCN and mPFC, and the metabolic pathways impacted by HFD were remarkably region-dependent. Furthermore, HFD induced a significant increase in the number of cycling metabolites exclusively in the SCN, revealing an unsuspected susceptibility of the master clock to food stress.

本文言語English
ページ(範囲)29904-29913
ページ数10
ジャーナルProceedings of the National Academy of Sciences of the United States of America
117
47
DOI
出版ステータスPublished - 2020 11月 24

ASJC Scopus subject areas

  • 一般

フィンガープリント

「Reshaping circadian metabolism in the suprachiasmatic nucleus and prefrontal cortex by nutritional challenge」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル