Resolution of hepatopulmonary syndrome after ligation of a portosystemic shunt in a pediatric patient with an Abernethy malformation

Nobuyuki Morikawa, Toshiro Honna, Tatsuo Kuroda, Yoshihiro Kitano, Yasushi Fuchimoto, Noriko Kawashima, Kazuteru Kawasaki

研究成果: Article査読

38 被引用数 (Scopus)

抄録

This report describes a case of Abernethy malformation associated with hepatopulmonary syndrome, which was resolved after shunt ligation. The clinical course indicated that hepatopulmonary syndrome can develop in Abernethy malformation in which liver function and portal pressure is normal, and liver transplantation is not the exclusive therapy for hepatopulmonary syndrome. The levels of endotoxin and endothelin 1 in the shunt blood were high, whereas those of tumor necrosis factor α and interleukin-1β were within reference range. Although pathogenesis of hepatopulmonary syndrome remains unknown, the findings in this case suggest that bacterial translocation as well as elevated endothelin 1 may play a causal role in development of hepatopulmonary syndrome.

本文言語English
ページ(範囲)e35-e38
ジャーナルJournal of Pediatric Surgery
43
2
DOI
出版ステータスPublished - 2008 2月 1

ASJC Scopus subject areas

  • 外科
  • 小児科学、周産期医学および子どもの健康

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