Resolvin E1 maintains macrophage function under cigarette smoke-induced oxidative stress

Rina Takamiya, Koichi Fukunaga, Makoto Arita, Jun Miyata, Hiroyuki Seki, Naoto Minematsu, Makoto Suematsu, Koichiro Asano

研究成果: Article査読

25 被引用数 (Scopus)

抄録

Cigarette smoke (CS) induces oxidative stress, which disables macrophage function. In this study, we examined whether Resolvin E1 (RvE1), a pro-resolving mediator known to enhance macrophage functions, attenuates the damage of macrophages by CS extract (CSE) induced oxidative stress. RvE1 blocked p47phox translocation to plasma membrane induced by CSE in a macrophage cell line, RAW264.7 cells, resulting in suppression of superoxide production. Furthermore, pretreatment of RAW264.7 cells with RvE1 restored the phagocytic activity and reduced cell death induced by treatment of CSE. These results suggest that RvE1 plays important roles in preserving macrophage function under CS-induced oxidative stress.

本文言語English
ページ(範囲)328-333
ページ数6
ジャーナルFEBS Open Bio
2
DOI
出版ステータスPublished - 2012

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)

フィンガープリント

「Resolvin E1 maintains macrophage function under cigarette smoke-induced oxidative stress」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル