Response to Fungal Dysbiosis by Gut-Resident CX3CR1 + Mononuclear Phagocytes Aggravates Allergic Airway Disease

Xin Li, Irina Leonardi, Alexa Semon, Itai Doron, Iris H. Gao, Gregory Garbès Putzel, Youngjun Kim, Hiroki Kabata, David Artis, William D. Fiers, Amanda E. Ramer-Tait, Iliyan D. Iliev

研究成果: Article査読

49 被引用数 (Scopus)

抄録

How mycobiota influence immunity in gut distal sites is not well understood. Li et al. developed protocols for gut-targeted depletion of phagocytes and mycobiota-free mice to investigate the influence of fungi on gut-lung crosstalk. They reveal that intestinal phagocytes sense fungal dysbiosis and mediate gut-lung-directed immunity to aggravate allergic airway disease.

本文言語English
ページ(範囲)847-856.e4
ジャーナルCell Host and Microbe
24
6
DOI
出版ステータスPublished - 2018 12 12
外部発表はい

ASJC Scopus subject areas

  • 寄生虫科
  • 微生物学
  • ウイルス学

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