Retrospective analysis of prognostic outcome of gastric cancer in young patients

Rieko Nakamura, Yoshirou Saikawa, Tsunehiro Takahashi, Hiroya Takeuchi, Humiki Asanuma, Yoshinori Yamada, Yuko Kitagawa

研究成果: Article査読

36 被引用数 (Scopus)

抄録

Background: It has been suggested that gastric cancer in young patients has a worse prognosis than in older patients, but this is controversial. This retrospective investigation was undertaken to understand the clinicopathological features and identify the prognostic factors of gastric cancer in young patients. Methods: Patients included in this study were those treated and followed up for gastric cancer from 1989 to 2005. Operative records, clinical, pathological, and follow-up data were reviewed. The critical age cut-off value for obtaining distinctive prognoses was 34 years. Results: Of 1730 gastric cancer patients whose records were reviewed, 27 were less than 34 years old (YGC group). The YGC group contained significantly higher percentages of females, stage IV, macroscopic type 4 tumors, poorly differentiated histology, peritoneal dissemination, and epigastric pain symptoms than the gastric cancer group aged 34 years or more (OGC group). Survival in the YGC group was significantly worse than in the OGC group (p = 0.0363). Ten-year survival was 68.5% in the YGC group and 81.8% in the OGC group. Survival in the YGC group was poorer for the stage IV patients, compared with OGC patients, especially for the stage IV patients with peritoneal dissemination and without liver metastases (H0P1 patients) (p = 0.049). Conclusions: Age in gastric cancer affects the prognosis, which in gastric cancer patients less than 34 years old was significantly poorer than for older patients, because of the high incidence of stage IV cancer with peritoneal dissemination in gastric cancer patients less than 34 years old.

本文言語English
ページ(範囲)328-334
ページ数7
ジャーナルInternational Journal of Clinical Oncology
16
4
DOI
出版ステータスPublished - 2011 8 1

ASJC Scopus subject areas

  • 外科
  • 血液学
  • 腫瘍学

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