Retrospective comparison of rectal toxicity between carbon-ion radiotherapy and intensity-modulated radiation therapy based on treatment plan, normal tissue complication probability model, and clinical outcomes in prostate cancer

Kyohei Fukata, Hidemasa Kawamura, Nobuteru Kubo, Tatsuaki Kanai, Masami Torikoshi, Takashi Nakano, Mutsumi Tashiro, Tatsuya Ohno

研究成果: Article査読

抄録

This retrospective study assessed the treatment planning data and clinical outcomes for 152 prostate cancer patients: 76 consecutive patients treated by carbon-ion radiation therapy and 76 consequtive patients treated by moderate hypo-fractionated intensity-modulated photon radiation therapy. These two modalities were compared using linear quadratic model equivalent doses in 2 Gy per fraction for rectal or rectal wall dose–volume histogram, 3.6 Gy per fraction-converted rectal dose–volume histogram, normal tissue complication probability model, and actual clinical outcomes. Carbon-ion radiation therapy was predicted to have a lower probability of rectal adverse events than intensity-modulated photon radiation therapy based on dose–volume histograms and normal tissue complication probability model. There was no difference in the clinical outcome of rectal adverse events between the two modalities compared in this study.

本文言語English
ページ(範囲)6-12
ページ数7
ジャーナルPhysica Medica
90
DOI
出版ステータスPublished - 2021 10

ASJC Scopus subject areas

  • 生物理学
  • 放射線学、核医学およびイメージング
  • 物理学および天文学(全般)

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