Revised structure and synthesis of celastramycin A, A potent innate immune suppressor

Haruhisa Kikuchi, Mizuki Sekiya, Yasuhiro Katou, Kazunori Ueda, Takahiro Kabeya, Shoichiro Kurata, Oshiteru Oshima

研究成果: Article査読

23 被引用数 (Scopus)

抄録

After searching for natural substances that regulate Innate Immunity using the ex vivo Drosophila culture system, a benzoyl pyrrole-type compound, celastramycin A, was Identified and Isolated as a potent suppressor. By synthesizing the previously reported structure 1 and another benzoyl pyrrole-type compound 2 reported In a Japanese patent, the correct structure of celastramycin A was confirmed to be 2. Compound 2 suppressed the production of IL-8 (IC50 0.06 μg/mL) In human umbilical vein endothelial cells (HUVECs).

本文言語English
ページ(範囲)1693-1695
ページ数3
ジャーナルOrganic Letters
11
8
DOI
出版ステータスPublished - 2009 4 16
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 物理化学および理論化学
  • 有機化学

フィンガープリント

「Revised structure and synthesis of celastramycin A, A potent innate immune suppressor」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル