Rheumatoid arthritis associated with methotrexate-induced pneumonitis: Improvement with i.v. cyclophosphamide therapy

Akira Suwa, Michito Hirakata, Shinji Satoh, Tsuneyo Mimori, Kenta Utsumi, Shinichi Inada

研究成果: Article査読

31 被引用数 (Scopus)

抄録

Pneumonitis is one of the most serious adverse effects associated with low-dose weekly methotrexate (MTX) therapy. Immediate cessation of MTX, and the introduction of oxygen therapy and glucocorticoids usually results in a dramatic improvement in the pulmonary toxicity. We report here a case of MTX- induced pneumonitis in a patient with rheumatoid arthritis (RA). Severe hypoxemia and interstitial infiltration in both lung fields did not respond to the withdrawal of MTX and the administration of oxygen and steroid pulse therapy. When intravenous cyclophosphamide (CYC) pulse therapy was initiated, however, rapid physiologic and radiographic improvement was seen. Our case suggests that CYC treatment may have a beneficial effect on MTX-induced pneumonitis that is resistant to steroid therapy.

本文言語English
ページ(範囲)355-358
ページ数4
ジャーナルClinical and experimental rheumatology
17
3
出版ステータスPublished - 1999 6 19

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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