(+)-Rhododendrol and epi-rhododendrin suppress the no production by activated macrophages in vivo

Shinji Fushiya, Yasuaki Kabe, Yasuaki Ikegaya, Fumihide Takano

研究成果: Article査読

20 被引用数 (Scopus)

抄録

In this study, we investigated the effect of (+)-rhododendrol (1) and epi-rhododendrin (2) isolated from Acer nikoense Maxim. (Aceraceae) on nitric oxide (NO) production in mouse peritoneal macrophages elicited by bacillus Calmette-Guerin and in vitro stimulated by lipopolysaccharide. The NO production was not affected by an oral administration of methanol extract at a dose of 100 mg/kg/day. However, the AcOEt soluble fraction significantly reduced the NO production. (+)-Rhododendrol (1) isolated as an active substance from the AcOEt fraction suppressed the NO production. epi- Rhododendrin (2), the glucoside of (+)-rhododendrol (1) isolated from the n- BuOH fraction, also suppressed the NO production. As NO is one of the critical mediators in inflammation, these results suggest that (+)- rhododendrol (1) and epi-rhododendrin (2) contribute in part to the anti- inflammatory effect of A. nikoense.

本文言語English
ページ(範囲)598-602
ページ数5
ジャーナルPlanta Medica
64
7
DOI
出版ステータスPublished - 1998 11 2
外部発表はい

ASJC Scopus subject areas

  • 分析化学
  • 分子医療
  • 薬理学
  • 薬科学
  • 創薬
  • 補完代替医療
  • 有機化学

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