Risk Factor for Vital Signs Fluctuation during Colonoscopy under Conscious Sedation Consisting of Midazolam and Meperidine

Shigeo Banno, Motohiko Kato, Yukie Sunata, Yuichiro Hirai, Yoko Kubosawa, Keiichiro Abe, Yoshiaki Takada, Tetsu Hirata, Yusaku Takatori, Michiko Wada, Satoshi Kinoshita, Hideki Mori, Kaoru Takabayashi, Masahiro Kikuchi, Toshio Uraoka

研究成果: Article

3 引用 (Scopus)

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Background: Sedatives or analgesics are widely used to relieve a patient's discomfort during colonoscopy (CS). Although cardiopulmonary adverse events are sometimes experienced during the examination, the risk factors for vital signs fluctuation (VSF) have not been fully elucidated. This study thus aimed to identify the risk factors for VSF during the examination, as well as to evaluate the frequency and the degree of VSF. Summary: A total of 755 consecutive subjects who received CS under endoscopist-administrated sedation using midazolam, meperidine, or combination of both were retrospectively analyzed. We assessed the distribution of vital signs during the procedure and frequency of VSF. To identify independent risk factors, we analyzed the association between VSF and subjects' characteristics and procedure information using the multivariate logistic regression model. Consequently, VSF was observed in 17% of all; hypotension and oxygen desaturation was observed in 13 and 5%, respectively. However, we could achieve the purpose of all procedure and, no one required hospitalization or extension of hospital stay. Multivariate analysis revealed that age (OR 1.05 [95% CI 1.04-1.07]), being female (OR 1.78 [95% CI 1.19-2.70]), and use of midazolam (OR 5.06 [95% CI 3.18-8.08]) were independent risk factors for VSF.

元の言語English
ジャーナルDigestive Diseases
DOI
出版物ステータスAccepted/In press - 2017 10 6
外部発表Yes

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ASJC Scopus subject areas

  • Gastroenterology

これを引用

Banno, S., Kato, M., Sunata, Y., Hirai, Y., Kubosawa, Y., Abe, K., Takada, Y., Hirata, T., Takatori, Y., Wada, M., Kinoshita, S., Mori, H., Takabayashi, K., Kikuchi, M., & Uraoka, T. (受理済み/印刷中). Risk Factor for Vital Signs Fluctuation during Colonoscopy under Conscious Sedation Consisting of Midazolam and Meperidine. Digestive Diseases. https://doi.org/10.1159/000481343