RNA binding proteins and the pathological cascade in ALS/FTD neurodegeneration

Daisuke Ito, Mami Hatano, Norihiro Suzuki

研究成果: Article査読

44 被引用数 (Scopus)

抄録

Advanced genetic approaches have accelerated the identification of causative genes linked to the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Most of the disease-related proteins encoded by these genes form aggregates in the cellular machineries that regulate RNA and protein quality control in cells. Cross-talk among the signaling pathways governing these machineries leads to pathological cascadesmediated by the accumulation of mutant RNA binding proteins.We outline themolecular basis of ALS and FTD pathogenesis and discuss the prospects for therapeutic strategies to treat these diseases.

本文言語English
論文番号5436
ジャーナルScience translational medicine
9
415
DOI
出版ステータスPublished - 2017 11 8

ASJC Scopus subject areas

  • 医学(全般)

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「RNA binding proteins and the pathological cascade in ALS/FTD neurodegeneration」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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