RNAi in transgenic animal models

Hidetoshi Hasuwa, Masaru Okabe

研究成果: Chapter

抄録

With completion of the “genome project” in human and mouse, we have entered the postgenome era, centered around the analysis of 30,000 to 40,000 gene functions. At present, ES cells and homologous recombination serve as powerful tools for many researchers aiming to elucidate the function of target genes in live animals. However, such methods are slow and cumbersome and are limited to mouse because of the technical difficulty in establishing ES cells in other species. Any improved technique should meet the following criteria: (a) simplicity of method to facilitate analysis of many genes in a short period of time, and (b) applicability to species other than mouse. RNAi could thus serve as an alternative, or supplemental, method to homologous re-combination.

本文言語English
ホスト出版物のタイトルGene Silencing by RNA Interference
ホスト出版物のサブタイトルTechnology and Application
出版社CRC Press
ページ289-297
ページ数9
ISBN(電子版)9780203489253
ISBN(印刷版)9780849321412
DOI
出版ステータスPublished - 2004 1 1
外部発表はい

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)
  • 医学(全般)

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