Robust bifurcation analysis for a genetic controller design problem for cell fate control

研究成果: Conference article査読

抄録

We propose a robustness analysis method for biomolecular controller design. First, we provide a computational method of bifurcation and robustness analysis for general nonlinear systems with dynamic uncertainties. We then apply the method to study a model that represents a genetic network system for controlling cell fates through external stimulus. In the network system, an artificial genetic controller is connected to the MAPK pathway. The proposed robust bifurcation method is used to determine design parameters of the controller for robustly achieving desired properties, in the presence of dynamic uncertainties.

本文言語English
ページ(範囲)53-58
ページ数6
ジャーナルIFAC-PapersOnLine
28
18
DOI
出版ステータスPublished - 2015 11月 1
イベント4th IFAC Conference on Analysis and Control of Chaotic Systems, CHAOS 2015 - Tokyo, Japan
継続期間: 2015 8月 262015 8月 28

ASJC Scopus subject areas

  • 制御およびシステム工学

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