Robust stability analysis for cyclic gene regulatory networks with uncertainty

Syuhei Osawa, Yutaka Hori, Shinji Hara

研究成果: Conference contribution

3 引用 (Scopus)

抜粋

This paper investigates robustness properties of gene regulatory networks with cyclic interconnections. In particular, we treat the heterogeneity of the gene's dynamics using a framework of robustness analysis, and derive necessary and sufficient conditions for robust stability. To this end, we first present a mathematical formulation of the gene regulatory network where dynamics of gene expression has a certain degree of uncertainty. Then, graphical and analytic criteria for robust stability are derived based on a robustness analysis scheme for large-scale multi-agent systems. These conditions are easily applicable to large-scale gene regulatory networks, which involve many components. Finally, the results are interpreted from a biological viewpoint, and they are verified by numerical simulations.

元の言語English
ホスト出版物のタイトルASCC 2011 - 8th Asian Control Conference - Final Program and Proceedings
ページ869-874
ページ数6
出版物ステータスPublished - 2011 8 29
外部発表Yes
イベント8th Asian Control Conference, ASCC 2011 - Kaohsiung, Taiwan, Province of China
継続期間: 2011 5 152011 5 18

出版物シリーズ

名前ASCC 2011 - 8th Asian Control Conference - Final Program and Proceedings

Other

Other8th Asian Control Conference, ASCC 2011
Taiwan, Province of China
Kaohsiung
期間11/5/1511/5/18

ASJC Scopus subject areas

  • Control and Systems Engineering

フィンガープリント Robust stability analysis for cyclic gene regulatory networks with uncertainty' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Osawa, S., Hori, Y., & Hara, S. (2011). Robust stability analysis for cyclic gene regulatory networks with uncertainty. : ASCC 2011 - 8th Asian Control Conference - Final Program and Proceedings (pp. 869-874). [5899186] (ASCC 2011 - 8th Asian Control Conference - Final Program and Proceedings).