Robustness analysis of genetic circuits onstructed by bottom-up strategy

Masaki Inoue, Takayuki Arai, Jun Ichi Imura, Kenji Kashima, Kazuyuki Aihara

研究成果: Conference contribution

抄録

We analyze the robustness of a system-level genetic circuit which is constructed by a bottom-up strategy. The latest trend in synthetic biology is to create large-scale and complex genetic circuits realizing desired programmable functions. An approach for the creation is bottom-up construction, that is, well-characterized small-scale circuits are coupled into large-scale system-level circuits involving desired programmable functions that can be predicted from the modules. However, in general, an intrinsic property in a circuit may be broken by internally connecting external circuits. We analyze a successful circuit created by a bottom-up construction strategy to identify the reason behind a successful synthesis. Utilizing the robustness analysis method based on the structured singular value, we can guarantee the validity of the bottom-up construction.

本文言語English
ホスト出版物のタイトル19th IFAC World Congress IFAC 2014, Proceedings
編集者Edward Boje, Xiaohua Xia
出版社IFAC Secretariat
ページ1736-1741
ページ数6
ISBN(電子版)9783902823625
DOI
出版ステータスPublished - 2014
外部発表はい
イベント19th IFAC World Congress on International Federation of Automatic Control, IFAC 2014 - Cape Town, South Africa
継続期間: 2014 8 242014 8 29

出版物シリーズ

名前IFAC Proceedings Volumes (IFAC-PapersOnline)
19
ISSN(印刷版)1474-6670

Other

Other19th IFAC World Congress on International Federation of Automatic Control, IFAC 2014
CountrySouth Africa
CityCape Town
Period14/8/2414/8/29

ASJC Scopus subject areas

  • Control and Systems Engineering

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