Rod-Shaped Neural Units for Aligned 3D Neural Network Connection

Midori Kato-Negishi, Hiroaki Onoe, Akane Ito, Shoji Takeuchi

研究成果: Article査読

26 被引用数 (Scopus)

抄録

This paper proposes neural tissue units with aligned nerve fibers (called rod-shaped neural units) that connect neural networks with aligned neurons. To make the proposed units, 3D fiber-shaped neural tissues covered with a calcium alginate hydrogel layer are prepared with a microfluidic system and are cut in an accurate and reproducible manner. These units have aligned nerve fibers inside the hydrogel layer and connectable points on both ends. By connecting the units with a poly(dimethylsiloxane) guide, 3D neural tissues can be constructed and maintained for more than two weeks of culture. In addition, neural networks can be formed between the different neural units via synaptic connections. Experimental results indicate that the proposed rod-shaped neural units are effective tools for the construction of spatially complex connections with aligned nerve fibers in vitro.

本文言語English
論文番号1700143
ジャーナルAdvanced Healthcare Materials
6
15
DOI
出版ステータスPublished - 2017 8月 9

ASJC Scopus subject areas

  • 生体材料
  • 生体医工学
  • 薬科学

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