Role of ADF/TRX and its inhibitor on the release of major basic protein from human eosinophils

Hideki Koyanagi, Naomi Wakasugi, Kentaro Yoshimatsu, Yuichiro Takashima, Junji J. Yodoi, Mariko Momoi, Toshio Suda, Tadashi Kasahara, Yuji Yamaguchi

研究成果: Article

6 被引用数 (Scopus)

抄録

Adult T cell leukemia-derived factor (ADF)/Thioredoxin (TRX), originally defined as an IL-2 receptor α-chain/p55 inducer, has many cytokine-like activities. We reported that the release of major basic protein (MBP) from mature eosinophils stimulated with cytochalasin B and C5a were augmented after preincubation with recombinant ADF/TRX. The addition of a TRX specific inhibitor, BE40644, suppressed the augmentation of MBP release from mature eosinophils. It is suggested that BE40644 is applicable in allergic diseases associated with eosinophils.

本文言語English
ページ(範囲)1140-1147
ページ数8
ジャーナルBiochemical and Biophysical Research Communications
213
3
DOI
出版ステータスPublished - 1995 1 1

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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