Role of adrenomedullin and its receptor system in renal pathophysiology

Masashi Mukoyama, Akira Sugawara, Tetsuya Nagae, Kiyoshi Mori, Hiroyuki Murabe, Hiroshi Itoh, Issei Tanaka, Kazuwa Nakao

研究成果: Article査読

18 被引用数 (Scopus)

抄録

Adrenomedullin (AM), a potent vasorelaxing, natriuretic and cell growth-modulating peptide, is thought to act as an autocrine/paracrine regulator in renal glomeruli and tubules. AM receptors comprise the calcitonin receptor-like receptor (CRLR) and a family of receptor-activity-modifying proteins (RAMPs 1-3); however, the pathophysiological role of AM and its receptor system in the kidney remains to be clarified. We examined the regulation of their expression in a rat model of renal injury and found that RAMP1, RAMP2 and CRLR expressions were markedly upregulated upon induction of fibrosis during obstructive nephropathy. Since AM exerts potent antiproliferative effects in various cell types, upregulation of the AM receptor system may play important roles in modulating the progression of renal diseases.

本文言語English
ページ(範囲)1925-1931
ページ数7
ジャーナルPeptides
22
11
DOI
出版ステータスPublished - 2001
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 生理学
  • 内分泌学
  • 細胞および分子神経科学

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