TY - JOUR
T1 - Role of DC-STAMP in cellular fusion of osteoclasts and macrophage giant cells
AU - Yagi, Mitsuru
AU - Miyamoto, Takeshi
AU - Toyama, Yoshiaki
AU - Suda, Toshio
PY - 2006/9/1
Y1 - 2006/9/1
N2 - Osteoclasts are the only cells that can resorb bone matrix physiologically and maintain the bone content. Osteoclasts are derived from macrophage/monocyte lineage cells; stimulation by macrophage colony stimulating factor and receptor activator of NFκB ligand induces osteoclastogenesis. During osteoclastogenesis, preosteoclasts fuse to form multinuclear mature osteoclasts. Cellular fusion is a unique phenomenon and enables fertilization, myotube formation, and efficient bone resorption in vertebrates. To date, several molecules have been reported to be fusion related in osteoclasts, namely CD44, CD47, ADAM12, MCP-1, and CD9, although the molecules which regulate osteoclast cellular fusion remain unclear. Here, we show that the seven-transmembrane- region receptor dendritic cell-specific transmembrane protein (DC-STAMP) is required for cell-cell fusion of osteoclasts and foreign body giant cells.
AB - Osteoclasts are the only cells that can resorb bone matrix physiologically and maintain the bone content. Osteoclasts are derived from macrophage/monocyte lineage cells; stimulation by macrophage colony stimulating factor and receptor activator of NFκB ligand induces osteoclastogenesis. During osteoclastogenesis, preosteoclasts fuse to form multinuclear mature osteoclasts. Cellular fusion is a unique phenomenon and enables fertilization, myotube formation, and efficient bone resorption in vertebrates. To date, several molecules have been reported to be fusion related in osteoclasts, namely CD44, CD47, ADAM12, MCP-1, and CD9, although the molecules which regulate osteoclast cellular fusion remain unclear. Here, we show that the seven-transmembrane- region receptor dendritic cell-specific transmembrane protein (DC-STAMP) is required for cell-cell fusion of osteoclasts and foreign body giant cells.
KW - DC-STAMP
KW - Foreign body giant cell
KW - Fusion
KW - Macrophage
KW - Osteoclast
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U2 - 10.1007/s00774-006-0697-9
DO - 10.1007/s00774-006-0697-9
M3 - Short survey
C2 - 16937266
AN - SCOPUS:33748107509
VL - 24
SP - 355
EP - 358
JO - Journal of Bone and Mineral Metabolism
JF - Journal of Bone and Mineral Metabolism
SN - 0914-8779
IS - 5
ER -