Role of extracellular damage-associated molecular pattern molecules (DAMPs) as mediators of persistent pain

Jungo Kato, Camilla I. Svensson

研究成果: Chapter

45 被引用数 (Scopus)

抄録

Damage-associated molecular pattern molecules (DAMPs) are endogenous molecules that are constitutively expressed and released upon tissue damage, resulting in activation of the immune system. In the absence of injury or infection, DAMPs play important intracellular roles. However, once released subsequent to cell damage or cell stress, DAMPs promote activation of innate immune cells and recruitment and activation of antigen-presenting cells engaged in host defense and tissue repair. This process involves pattern recognition receptors, such as the Toll-like receptors (TLRs) and receptor for advanced glycation end products (RAGE). Several of the TLRs and RAGE have been implicated to play key roles not only in the detection of injury but also in pain signaling. Pain-like behavior is reduced in TLR2- and TLR4-deficient mice, and after injection of TLR2-, TLR4-, and RAGE antagonists in experimental models of nerve injury, arthritis, and bone cancer pain. This suggests that the pathological processes in these models are associated with release of endogenous TLR and RAGE ligands, and further that DAMPs play an important role in persistent pain. There is now a rapidly growing list of DAMPs in the literature and here we give an overview of DAMPs that have been associated with nociceptive signaling.

本文言語English
ホスト出版物のタイトルProgress in Molecular Biology and Translational Science
出版社Elsevier B.V.
ページ251-279
ページ数29
DOI
出版ステータスPublished - 2015
外部発表はい

出版物シリーズ

名前Progress in Molecular Biology and Translational Science
131
ISSN(印刷版)1877-1173
ISSN(電子版)1878-0814

ASJC Scopus subject areas

  • 分子医療
  • 分子生物学

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