抄録
Hepatic tumors including hepatocellular carcinoma were generated by carbon tetrachloride in transgenic mice carrying a human c-H-ras gene (rasH2 mice). RasH2 mice express 2 to 3 times more ras protein (ras p21) in the liver than do non-Tg mice. When carbon tetrachloride was administered, the rasH2 mice produced about 5 times as many hepatic tumors than did the non-transgenic mice. However, neither the 10-100 times higher ras p21 expression required for murine fibroblast transformation by itself nor the mutational activation of the H-ras gene was observed in carbon tetrachloride-induced hepatic tumors. These results show that H-ras proto-oncogene expression in the murine liver, even if it is not high enough to transform cells, also causes liver tumors when CCl4 are repeatedly given.
本文言語 | English |
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ページ(範囲) | 371-379 |
ページ数 | 9 |
ジャーナル | Biochemistry and Molecular Biology International |
巻 | 42 |
号 | 2 |
出版ステータス | Published - 1997 6月 1 |
ASJC Scopus subject areas
- 生化学
- 分子生物学
- 遺伝学