Role of macrophage migration inhibitory factor in bleomycin-induced lung injury and fibrosis in mice

Yoshinori Tanino, Hironi Makita, Kenji Miyamoto, Tomoko Betsuyaku, Yoshinori Ohtsuka, Jun Nishihira, Masaharu Nishimura

研究成果: Article査読

67 被引用数 (Scopus)

抄録

Macrophage migration inhibitory factor (MIF) is a unique cytokine that reportedly overrides the anti-inflammatory effect of endogenous glucocorticoids. MIF has been demonstrated to be involved in a variety of inflammatory diseases. In this study, we examined the role of MIF in bleomycin (BLM)-induced lung injury and fibrosis. The levels of MIF in lung tissues and bronchoalveolar lavage fluids were significantly increased in the period 5-10 days after intratracheal administration of BLM. Treatment with the anti-MIF antibody significantly reduced the mortality at 14 days and the histopathological lung injury score at 10 days. These effects were accompanied with significant suppression of the accumulation of inflammatory cells in the alveolar space and tumor necrosis factor-α in the lungs at 7 days. However, the anti-MIF antibody did not affect either the content of lung hydroxyproline or the histopathological lung fibrosis score at 21 days after BLM. These data provide further evidence for the crucial role of MIF in acute lung inflammation but do not support the involvement of MIF in lung fibrosis induced by BLM in mice.

本文言語English
ページ(範囲)L156-L162
ジャーナルAmerican Journal of Physiology - Lung Cellular and Molecular Physiology
283
1 27-1
DOI
出版ステータスPublished - 2002

ASJC Scopus subject areas

  • 生理学
  • 呼吸器内科
  • 生理学(医学)
  • 細胞生物学

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