TY - JOUR
T1 - Role of micrornas-221/222 in digestive systems
AU - Matsuzaki, Juntaro
AU - Suzuki, Hidekazu
N1 - Publisher Copyright:
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
PY - 2015/8/6
Y1 - 2015/8/6
N2 - MiR-221 and miR-222 (miR-221/222) are well-studied oncogenic microRNAs that are frequently upregulated in several types of human tumors, such as esophageal adenocarcinoma, gastric adenocarcinoma, colorectal adenocarcinoma, hepatocellular carcinoma, and pancreatic ductal adenocarcinoma. In these cancers, silencing miR-221/222 could represent a novel anti-tumor approach to inhibit tumor growth and metastasis. On the other hand, miR-221/222 also play onco-suppressive roles in cholangiocarcinoma and gastrointestinal stromal tumors (GISTs). Here we will review the roles of miR-221/222 in digestive systems and their possibility as prognostic and therapeutic tools.
AB - MiR-221 and miR-222 (miR-221/222) are well-studied oncogenic microRNAs that are frequently upregulated in several types of human tumors, such as esophageal adenocarcinoma, gastric adenocarcinoma, colorectal adenocarcinoma, hepatocellular carcinoma, and pancreatic ductal adenocarcinoma. In these cancers, silencing miR-221/222 could represent a novel anti-tumor approach to inhibit tumor growth and metastasis. On the other hand, miR-221/222 also play onco-suppressive roles in cholangiocarcinoma and gastrointestinal stromal tumors (GISTs). Here we will review the roles of miR-221/222 in digestive systems and their possibility as prognostic and therapeutic tools.
KW - Colorectal cancer
KW - Hepatocellular carcinoma
KW - MicroRNA
KW - Pancreatic cancer
UR - http://www.scopus.com/inward/record.url?scp=85048836549&partnerID=8YFLogxK
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U2 - 10.3390/jcm4081566
DO - 10.3390/jcm4081566
M3 - Review article
AN - SCOPUS:85048836549
SN - 2077-0383
VL - 4
SP - 1566
EP - 1577
JO - Journal of Clinical Medicine
JF - Journal of Clinical Medicine
IS - 8
ER -
