Role of Peyer's patches in the induction of Helicobacter pylori-induced gastritis

Shigenori Nagai, Hitomi Mimuro, Taketo Yamada, Yukiko Baba, Kazuyo Moro, Tomonori Nochi, Hiroshi Kiyono, Toshihiko Suzuki, Chihiro Sasakawa, Shigeo Koyasu

研究成果: Article

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Helicobacter pylori is a Gram-negative spiral bacterium that causes gastritis and peptic ulcer and has been implicated in the pathogenesis of gastric adenocarcinoma and mucosa-associated lymphoid tissue lymphoma. Although Th1 immunity is involved in gastritis and the accumulation of H. pylori-specific CD4+ T cells in the H. pylori-infected gastric mucosa in human patients, how T cells are primed with H. pylori antigens is unknown because no apparent lymphoid tissues are present in the stomach. We demonstrate here that Peyer's patches (PPs) in the small intestine play critical roles in H. pylori-induced gastritis; no gastritis is induced in H. pylori-infected mice lacking PPs. We also observed that the coccoid form of H. pylori is phagocytosed by dendritic cells in PPs. We propose that H. pylori converts to the coccoid form in the anaerobic small intestine and stimulates the host immune system through PPs.

元の言語English
ページ(範囲)8971-8976
ページ数6
ジャーナルProceedings of the National Academy of Sciences of the United States of America
104
発行部数21
DOI
出版物ステータスPublished - 2007 5 22

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  • General

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    Nagai, S., Mimuro, H., Yamada, T., Baba, Y., Moro, K., Nochi, T., Kiyono, H., Suzuki, T., Sasakawa, C., & Koyasu, S. (2007). Role of Peyer's patches in the induction of Helicobacter pylori-induced gastritis. Proceedings of the National Academy of Sciences of the United States of America, 104(21), 8971-8976. https://doi.org/10.1073/pnas.0609014104