Role of phosphoenolpyruvate in the NADP-isocitrate dehydrogenase and isocitrate lyase reaction in Escherichia coli

Tadashi Ogawa, Keiko Murakami, Hirotada Mori, Nobuyoshi Ishii, Masaru Tomita, Masataka Yoshin

研究成果: Article査読

16 被引用数 (Scopus)

抄録

Phosphoenolpyruvate inhibited Escherichia coli NADP-isocitrate dehydrogenase allosterically (Ki of 0.31 mM) and isocitrate lyase uncompetitively (Ki′ of 0.893 mM). Phosphoenolpyruvate enhances the uncompetitive inhibition of isocitrate lyase by increasing isocitrate, which protects isocitrate dehydrogenase from the inhibition, and contributes to the control through the tricarboxylic acid cycle and glyoxylate shunt.

本文言語English
ページ(範囲)1176-1178
ページ数3
ジャーナルJournal of Bacteriology
189
3
DOI
出版ステータスPublished - 2007 2

ASJC Scopus subject areas

  • 微生物学
  • 分子生物学

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