Role of PI3K/Akt and mTOR complexes in Th17 cell differentiation

Shigenori Nagai, Yutaka Kurebayashi, Shigeo Koyasu

研究成果: Article

53 引用 (Scopus)

抄録

Interleukin (IL)-17-producing helper T (Th17) cells serve as a Th subset involved in epithelial cell- and neutrophil-mediated immune responses against extracellular microbes and in the development of various autoimmune diseases. The differentiation of Th17 cells is controlled by a number of intracellular signaling cascades and a complex network of transcription factors. Recently, it has been shown that PI3K, Akt, and mammalian target of rapamycin (mTOR) complexes, such as mTORC1 and mTORC2, also positively regulate Th17 differentiation both in vivo and in vitro via multiple mechanisms; here, we review the current knowledge regarding the mechanisms through which these molecules enhance Th17 differentiation.

元の言語English
ページ(範囲)30-34
ページ数5
ジャーナルAnnals of the New York Academy of Sciences
1280
発行部数1
DOI
出版物ステータスPublished - 2013 3

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Th17 Cells
Interleukin-17
Complex networks
Sirolimus
Phosphatidylinositol 3-Kinases
Cell Differentiation
Transcription Factors
Molecules
Helper-Inducer T-Lymphocytes
Autoimmune Diseases
Neutrophils
Epithelial Cells
mechanistic target of rapamycin complex 1
TOR complex 2
Cells
In Vitro Techniques

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

これを引用

Role of PI3K/Akt and mTOR complexes in Th17 cell differentiation. / Nagai, Shigenori; Kurebayashi, Yutaka; Koyasu, Shigeo.

:: Annals of the New York Academy of Sciences, 巻 1280, 番号 1, 03.2013, p. 30-34.

研究成果: Article

Nagai, Shigenori ; Kurebayashi, Yutaka ; Koyasu, Shigeo. / Role of PI3K/Akt and mTOR complexes in Th17 cell differentiation. :: Annals of the New York Academy of Sciences. 2013 ; 巻 1280, 番号 1. pp. 30-34.
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