Role of protein kinase A in regulating steroid sulfate uptake for estrogen production in human placental choriocarcinoma cells

M. Tomi, Y. Miyata, S. Noguchi, S. Nishimura, T. Nishimura, E. Nakashima

研究成果: Article査読

7 被引用数 (Scopus)

抄録

The purpose of this study is to assess the role of the protein kinase A (PKA) in regulating uptake of dehydroepiandrosterone sulfate (DHEAS), an estrogen precursor, by syncytiotrophoblasts. Forskolin, a PKA activator, significantly increased [3H]DHEAS uptake and the mRNA expression levels of organic anion transporter (OAT) 4 and CYP19A1 in choriocarcinoma JEG-3 cells, while other steroid sulfate transporters present in the placenta showed no change in expression level. KT5720, a PKA inhibitor, attenuated these effects of forskolin. Accordingly, the PKA pathway appears to play an important role in estrogen synthesis by cooperatively regulating OAT4 and steroidogenic enzymes in syncytiotrophoblasts.

本文言語English
ページ(範囲)658-660
ページ数3
ジャーナルPlacenta
35
8
DOI
出版ステータスPublished - 2014 8

ASJC Scopus subject areas

  • 生殖医学
  • 産婦人科学
  • 発生生物学

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