Role of reactive metabolites of oxygen and nitrogen in partial liver transplantation: Lessons learned from reduced-size liver ischaemia and reperfusion injury

Hidejiro Urakami, Yuta Abe, Matthew B. Grisham

研究成果: Review article査読

33 被引用数 (Scopus)

抄録

1. Hepatic resection with concomitant periods of ischaemia and reperfusion (I/R) is required to perform reduced-size liver (RSL) transplantation procedures, such as living donor or split liver transplantation. Although a great deal of progress has been made using these types of surgical procedures, a significant number of patients develop tissue injury from these procedures, ultimately resulting in graft failure. 2. Because of this, there is a real need to understand the different mechanisms responsible for the tissue injury induced by I/R of RSL transplantation (RSL + I/R), with the ultimate goal to develop new and improved therapeutic agents that may limit the tissue damage incurred during RSL transplantation. 3. The present paper reviews the recent studies that have been performed examining the role of reactive metabolites of oxygen and nitrogen in a mouse model of RSL + I/R. In addition, we present data demonstrating how the pathophysiological mechanisms identified in this model compare with those observed in a model of RSL transplantation in rats.

本文言語English
ページ(範囲)912-919
ページ数8
ジャーナルClinical and Experimental Pharmacology and Physiology
34
9
DOI
出版ステータスPublished - 2007 9
外部発表はい

ASJC Scopus subject areas

  • 生理学
  • 薬理学
  • 生理学(医学)

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